Xenophage: Alien BloodSport is a versus fighting game starring somewhat unusual combatants: aliens. Eight alien fighters have been gathered on a space ship to fight each other to death. The Story Mode has the player follow this tournament from the point of view of one of the aliens; Free Play mode allows players to pit them against each other in any combination.
The gameplay follows the conventions of 2D fighting games; however, the characters are rendered in 3D. The camera follows the combatants, zooming in and out on the screen. The game includes considerable amount of gore (which can be adjusted), as well as special moves unique to each fighter, dubbed "humiliations".